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Angiotensin 1-7 (ANG 1-7)
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Detailed information
1. Basic Information
Product Name: Angiotensin 1-7 (ANG 1-7)
English name: Angiotensin(1-7)
Amino acid sequence: Asp-Arg-Val-Tyr-Ile-His-Pro
Molecular formula: C 43 H 65 N 12 O 12
Molecular weight: 941.2
CAS Number: 51833-78-4
Structural diagram:
2. Feature Introduction
Mechanism of action
Antagonizing the effects of Ang II: inhibiting the binding of Ang II to the AT1 receptor, thereby reducing oxidative stress, inflammation, and fibrosis.
NO/cGMP pathway: Activates endothelial nitric oxide synthase (eNOS), increases nitric oxide (NO) release, and leads to vasodilation.
Anti-inflammatory and antioxidant effects: Inhibits the NF-κB pathway, reducing the production of pro-inflammatory cytokines (such as TNF-α and IL-6) and reactive oxygen species (ROS).
Anti-proliferative and anti-fibrotic effects: Inhibiting the MAPK and PI3K/Akt pathways to reduce cell proliferation and collagen deposition.
Physiological and pharmacological effects
Cardiovascular system
Vasodilation: Counteracts the vasoconstrictive effects of Ang II via an NO-dependent mechanism and improves endothelial function.
Cardiac protection: inhibits cardiomyocyte hypertrophy and fibrosis, alleviates myocardial ischemia-reperfusion injury, and reduces infarct size.
Hypotensive effect: Balances the renin-angiotensin system (RAS) and lowers blood pressure (particularly effective for salt-sensitive hypertension).
Kidney protection
Diuresis and natriuresis: Increase renal blood flow, promote sodium excretion, and reduce water and sodium retention.
Anti-fibrotic: Inhibits glomerular sclerosis and renal interstitial fibrosis, thereby slowing the progression of chronic kidney disease.
Anti-proteinuria: Protects the glomerular filtration barrier and reduces proteinuria in diabetic nephropathy.
Metabolic regulation
Improve insulin sensitivity: By inhibiting adipose tissue inflammation and oxidative stress, and enhancing insulin signaling pathways (such as PI3K/Akt).
Regulate lipid metabolism: Reduce plasma triglyceride and low-density lipoprotein (LDL) levels.
Anti-inflammatory and Immunomodulatory
Inhibit inflammatory cell infiltration: Reduce the recruitment of macrophages and neutrophils to damaged tissues.
Regulate immune responses: Inhibit Th17 cell differentiation and promote the function of regulatory T cells (Tregs).
Other effects
Neuroprotection: Reducing oxidative stress in cerebral ischemic injury and neurodegenerative diseases.
Anti-atherosclerotic: Inhibits the proliferation of vascular smooth muscle cells and the formation of foam cells.
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