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KPV tripeptide α-MSH (11-13)
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Detailed information
1. Basic Information
Product Name: KPV Tripeptide
English name: α-MSH (11-13)
Amino acid sequence: Lys-Pro-Val
Molecular formula: C 16 H 30 N 4 O 4
Molecular weight: 342.43
CAS Number: 67727-97-3
Structural diagram:
2. Feature Introduction
Mechanism of action
Anti-inflammatory and Immunomodulatory Effects: NF-κB Pathway Inhibition—Blocking the Release of Inflammatory Cytokines (such as IL-1β and TNF-α).
MAPK signaling regulation: Downregulation of p38 and JNK phosphorylation alleviates the inflammatory response.
Antioxidant: Scavenges free radicals and reduces oxidative stress damage.
Target receptor: Some anti-inflammatory effects may be mediated via melanocortin receptors (MC1R/MC3R) (associated with the structure of α-MSH).
Non-receptor-dependent pathway: directly interacts with cell membrane or intracellular proteins.
Physiological and pharmacological effects
Anti-inflammatory and Immunomodulatory:
Skin inflammation: Alleviates erythema and swelling in eczema and psoriasis models.
Gut protection: Ameliorates colitis (such as DSS-induced inflammatory bowel disease) and reduces intestinal barrier disruption.
Systemic Inflammation: Suppressing the Cytokine Storm in Sepsis Models.
Tissue repair:
Skin healing: Promotes keratinocyte migration and accelerates epidermal repair.
Mucosal repair: Protects the gastric mucosa and reduces ulcers induced by alcohol or NSAIDs.
Neuroprotection: Reducing neuroinflammation (such as microglial activation in Alzheimer’s disease models).
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