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Thymic Pentapeptide (TP5)
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Detailed information
1 . Basic Information
Product Name: Thymosin Pentapeptide (TP5)
English name: Thymopentin
Amino acid sequence: Arg - Lys - Asp - Val - Tyr
Molecular formula: C 30 H 49 N 9 O 9
Molecular weight: 679.77
CAS Number: 69558-55-0
Structural diagram:
2. Feature Introduction
Mechanism of action
T-cell differentiation and maturation: By activating thymic cells and peripheral T cells, it promotes the balance between CD4+ (helper T cells) and CD8+ (cytotoxic T cells) subsets.
Cytokine regulation: Enhances the secretion of Th1-type cytokines such as IL-2 and IFN-γ, while suppressing excessive Th2 responses (e.g., IL-4).
Neuroendocrine regulation: May indirectly influence immune function via the hypothalamic-pituitary-adrenal (HPA) axis.
Physiological and pharmacological effects
Enhanced Immune Function: Boosts T-cell function in patients with immune deficiencies (such as those following chemotherapy or experiencing age-related immune decline); supports immune reconstitution after viral infections (e.g., hepatitis B, HIV) and after cancer radiotherapy and chemotherapy.
Anti-inflammatory and Autoimmune Regulation: Demonstrates bidirectional regulatory effects (inhibiting excessive autoimmune responses) in models of rheumatoid arthritis and systemic lupus erythematosus (SLE).
Other potential effects: antioxidant stress (reducing ROS), and promotion of wound healing (via the VEGF pathway).
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