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Cyclo(his-pro)
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Detailed information
1. Basic Information
Product Name: Cyclo(his-pro)
English name: Cyclo(his-pro)
Amino acid sequence: His-Pro
Molecular formula: C 11 H 14 N 4 O 2
Molecular weight: 234.25
CAS Number: 53109-32-3
Structural diagram:
2. Feature Introduction
Mechanism of action
Neuroendocrine regulation: Regulates the hypothalamic-pituitary axis, influencing the secretion of thyroid-stimulating hormone (TSH) and growth hormone (GH); indirectly participates in neural signal transmission by modulating TRH metabolism.
Metal ion chelation: Binds metal ions such as zinc (Zn²⁺) and copper (Cu²⁺), thereby affecting the activity of metal-dependent enzymes.
Antioxidant and anti-inflammatory effects: Scavenges free radicals (such as hydroxyl radicals) and inhibits lipid peroxidation; downregulates the NF-κB pathway, thereby reducing the release of inflammatory cytokines such as TNF-α and IL-6.
Physiological and pharmacological effects
Neuroprotection: Reducing neuronal damage caused by oxidative stress (such as the toxicity of β-amyloid in Alzheimer’s disease models); improving neurological functional recovery after cerebral ischemia-reperfusion injury.
Metabolic regulation: Modulates appetite-related neuropeptides (such as NPY and POMC), influencing energy balance; improves insulin sensitivity and holds potential for diabetes management.
Immune modulation: Suppresses excessive immune responses and alleviates symptoms of experimental autoimmune encephalomyelitis (EAE).
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