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Delta Sleep-Inducing Peptide (DSIP)
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Detailed information
1. Basic Information
Product Name: δ-Sleep Inducing Peptide (DSIP)
English name: δ-Sleep Inducing Peptide
Amino acid sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
Molecular formula: C 35 H 48 N 10 O 15
Molecular weight: 848.81
CAS Number: 62568-57-4
Structural diagram:
2. Feature Introduction
Mechanism of action
Neurotransmitter modulation: promotes GABAergic neuronal activity, inhibits glutamatergic excitatory transmission, and enhances sedative effects.
Hypothalamic-pituitary axis: Regulates the release of adrenocorticotropic hormone (ACTH) and cortisol, indirectly influencing the sleep-wake cycle.
Antioxidant and anti-stress effects: Reduces markers of oxidative stress and alleviates stress-induced sleep disturbances.
Target brain regions: Primarily affects the hypothalamus, thalamus, and reticular formation of the brainstem, promoting slow-wave sleep (delta-wave sleep).
Physiological and pharmacological effects
Sleep regulation: Specifically enhances slow-wave sleep (SWS), prolongs the duration of deep sleep, and improves sleep quality; regulates circadian rhythms, particularly promoting sleep recovery after sleep deprivation.
Neuroprotection: Alleviates cerebral ischemia-reperfusion injury and inhibits neuronal apoptosis; potentially exhibits anti-anxiety and antidepressant effects.
Metabolic regulation: Affects energy metabolism and may be associated with the regulation of carbohydrate and lipid metabolism during sleep.
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